Article
Association of acetylated histones with paternally expressed genes in the Prader--Willi deletion region.
Human molecular genetics - 15 Mar 2001
Fulmer-Smentek S B, Francke U
Abstract excerpt
Imprinted genes within the Prader-Willi/Angelman syndrome region of human chromosome 15q11-q13 are regulated by a mechanism involving allele-specific DNA methylation. Since transcriptional regulation by DNA methylation involves histone deacetylation, we explored whether differences in histone acetylation exist between the two parental alleles of SNRPN and other paternally expressed genes in the region by using a...
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