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Article

Partial Loss of Presenilin Impairs Age-Dependent Neuronal Survival in the Cerebral Cortex

26 Nov 2014

Abstract excerpt

Mutations in the presenilin (PSEN1 and PSEN2) genes are linked to familial Alzheimer's disease (AD) and cause loss of its essential function. Complete inactivation of presenilins in excitatory neurons of the adult mouse cerebral cortex results in progressive memory impairment and age-dependent neurodegeneration, recapitulating key features of AD. In this study, we examine the effects of varying presenilin dosage...

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PMID: 25429133
DOI: 10.1523/jneurosci.3261-14.2014

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