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Article

Role of Arabidopsis ARGONAUTE4 in RNA-directed DNA methylation triggered by inverted repeats.

Current biology : CB - 13 Jul 2004

Zilberman Daniel, Cao Xiaofeng, Johansen Lisa K, Xie Zhixin, Carrington James C, Jacobsen Steven E

Abstract excerpt

In a number of organisms, transgenes containing transcribed inverted repeats (IRs) that produce hairpin RNA can trigger RNA-mediated silencing, which is associated with 21-24 nucleotide small interfering RNAs (siRNAs). In plants, IR-driven RNA silencing also causes extensive cytosine methylation of homologous DNA in both the transgene "trigger" and any other homologous DNA sequences--"targets". Endogenous genomic...

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Share to Argonaute Proteins
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 15242620
DOI: 10.1016/j.cub.2004.06.055

Genes

AGO4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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