Article
ARGONAUTE4 control of locus-specific siRNA accumulation and DNA and histone methylation.
Science (New York, N.Y.) - 31 Jan 2003
Zilberman Daniel, Cao Xiaofeng, Jacobsen Steven E
Abstract excerpt
Proteins of the ARGONAUTE family are important in diverse posttranscriptional RNA-mediated gene-silencing systems as well as in transcriptional gene silencing in Drosophila and fission yeast and in programmed DNA elimination in Tetrahymena. We cloned ARGONAUTE4 (AGO4) from a screen for mutants that suppress silencing of the Arabidopsis SUPERMAN (SUP) gene. The ago4-1 mutant reactivated silent SUP alleles and...
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