Article
An effector of RNA-directed DNA methylation in arabidopsis is an ARGONAUTE 4- and RNA-binding protein.
Cell - 1 May 2009
He Xin-Jian, Hsu Yi-Feng, Zhu Shihua, Wierzbicki Andrzej T, Pontes Olga, Pikaard Craig S, Liu Hai-Liang, Wang Co-Shine, Jin Hailing, Zhu Jian-Kang
Abstract excerpt
DNA methylation is a conserved epigenetic mark in plants and mammals. In Arabidopsis, DNA methylation can be triggered by small interfering RNAs (siRNAs) through an RNA-directed DNA methylation (RdDM) pathway. Here, we report the identification of an RdDM effector, KTF1. Loss-of-function mutations in KTF1 reduce DNA methylation and release the silencing of RdDM target loci without abolishing the siRNA triggers....
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