Article
Identification and utilization of arbitrary correlations in models of recombination signal sequences.
Genome biology - 1 Jan 2002
Cowell Lindsay G, Davila Marco, Kepler Thomas B, Kelsoe Garnett
Abstract excerpt
BACKGROUND: A significant challenge in bioinformatics is to develop methods for detecting and modeling patterns in variable DNA sequence sites, such as protein-binding sites in regulatory DNA. Current approaches sometimes perform poorly when positions in the site do not independently affect protein binding. We developed a statistical technique for modeling the correlation structure in variable DNA sequence sites....
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