Article
Activated Ets2 is required for persistent inflammatory responses in the motheaten viable model.
Journal of immunology (Baltimore, Md. : 1950) - 15 Jul 2004
Wei Guo, Guo Jianping, Doseff Andrea I, Kusewitt Donna F, Man Albert K, Oshima Robert G, Ostrowski Michael C
Abstract excerpt
The Ets2 transcription factor is constitutively phosphorylated on residue Thr(72) in macrophages derived from mice homozygous for the motheaten viable (me-v) allele of the hemopoietic cell phosphatase (Hcph) gene. To genetically test the importance of signaling through residue Thr(72) of Ets2 during inflammation, the Ets2(A72) mutant allele, which cannot be phosphorylated on Thr(72), was combined with the...
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