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Article

Ets2-dependent stromal regulation of mouse mammary tumors.

Molecular and cellular biology - 1 Dec 2003

Man Albert K, Young Lawrence J T, Tynan John A, Lesperance Jacqueline, Egeblad Mikala, Werb Zena, Hauser Craig A, Muller William J, Cardiff Robert D, Oshima Robert G

Abstract excerpt

The Ets2 transcription factor is regulated by mitogen-activated protein (MAP) kinase phosphorylation of a single threonine residue. We generated by gene targeting a single codon mutation in Ets2 substituting Ala for the critical Thr-72 phosphorylation site (Ets2A72), to investigate the importance of MAP kinase activation of Ets2 in embryo and tumor development. Ets2(A72/A72) mice are viable and develop normally....

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Source

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Identifiers

PMID: 14612405
DOI: 10.1128/MCB.23.23.8614-8625.2003
PMCID: PMC262691

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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