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Article

Molecular basis of the motheaten phenotype.

Immunological reviews - 1 Apr 1994

Tsui F W, Tsui H W

Abstract excerpt

Mice homozygous for the autosomal recessive motheaten (me) or the allelic viable motheaten (mev) mutations manifest a unique immunological disease associated with severe immunodeficiency and autoimmunity. Over the past few years, our group has used the motheaten mouse as a model system for elucidating the genetic and cellular events that contribute to expression of normal hematopoietic and immune cell function....

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Identifiers

PMID: 8070815
DOI: 10.1111/j.1600-065x.1994.tb00852.x

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Molecular basis of the motheaten phenotype.PMID 8070815Read ↗

Mutations at the murine motheaten locus are within the hematopoietic cell protein-tyrosine phosphatase (Hcph) gene.Semantic proximity Read ↗

Motheaten and viable motheaten mice have mutations in the haematopoietic cell phosphatase gene.Semantic proximity Read ↗

Identification of PTP1C mutation as the genetic defect in motheaten and viable motheaten mice: a step toward defining the roles of protein tyrosine phosphatases in the regulation of hemopoietic cell differentiation and function.Semantic proximity Read ↗

B and T cells are not required for the viable motheaten phenotype.Semantic proximity Read ↗

Distinct roles for neutrophils and dendritic cells in inflammation and autoimmunity in motheaten mice.Semantic proximity Read ↗

Establishment and characterization of pro-B cell lines from motheaten mutant mouse defective in SHP-1 protein tyrosine phosphatase.Semantic proximity Read ↗

Investigations into the regulation and function of the SH2 domain-containing protein-tyrosine phosphatase, SHP-1.Semantic proximity Read ↗

SHP-1 variant proteins are absent in motheaten mice despite presence of splice variant transcripts with open reading frames.Semantic proximity Read ↗

Activated Ets2 is required for persistent inflammatory responses in the motheaten viable model.Semantic proximity Read ↗

Deficiency of SHP-1 protein-tyrosine phosphatase activity results in heightened osteoclast function and decreased bone density.Semantic proximity Read ↗

Mutation of the hematopoietic cell phosphatase (Hcph) gene is associated with resistance to gamma-irradiation-induced apoptosis in Src homology protein tyrosine phosphatase (SHP)-1-deficient "motheaten" mutant mice.Semantic proximity Read ↗

DNA-binding antibodies from viable motheaten mutant mice: implications for B cell tolerance.Semantic proximity Read ↗

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