Increased myeloid cell responses to M-CSF and RANKL cause bone loss and inflammation in SH3BP2 "cherubism" mice.

doi:10.1016/j.cell.2006.10.047

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Article

Increased myeloid cell responses to M-CSF and RANKL cause bone loss and inflammation in SH3BP2 "cherubism" mice.

Cell - 12 Jan 2007

Ueki Yasuyoshi, Lin Chin-Yu, Senoo Makoto, Ebihara Takeshi, Agata Naoki, Onji Masahiro, Saheki Yasunori, Kawai Toshihisa, Mukherjee Padma M, Reichenberger Ernst, Olsen Bjorn R

Abstract excerpt

While studies of the adaptor SH3BP2 have implicated a role in receptor-mediated signaling in mast cells and lymphocytes, they have failed to identify its function or explain why SH3BP2 missense mutations cause bone loss and inflammation in patients with cherubism. We demonstrate that Sh3bp2 "cherubism" mice exhibit trabecular bone loss, TNF-alpha-dependent systemic inflammation, and cortical bone erosion. The...

Topics

Adaptor Proteins, Signal Transducing
Animals
Arginine
Bone Marrow Cells
Bone Resorption
CD11b Antigen
Cell Differentiation
Cherubism
Disease Models, Animal
Hematologic Diseases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Homozygote

Inflammation

Intracellular Signaling Peptides and Proteins

Lymph Nodes

Macrophage Colony-Stimulating Factor

Mice

Mitogen-Activated Protein Kinase 1

Mitogen-Activated Protein Kinase 3

Source

Open in PubMed

Identifiers

PMID: 17218256
DOI: 10.1016/j.cell.2006.10.047

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