Article
Evolution of resistance to drugs in HIV-1-infected patients failing antiretroviral therapy.
AIDS (London, England) - 23 Jul 2004
Kantor Rami, Shafer Robert W, Follansbee Stephen, Taylor Jonathan, Shilane David, Hurley Leo, Nguyen Dong-Phuong, Katzenstein David, Fessel W Jeffrey
Abstract excerpt
BACKGROUND AND OBJECTIVE: The optimal time for changing failing antiretroviral therapy (ART) is not known. It involves balancing the risk of exhausting future treatment options against the risk of developing increased drug resistance. The frequency with which new drug-resistance mutations (DRM) developed and their potential consequences in patients continuing unchanged treatment despite persistent viremia were...
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