Article
Drug-class-wide resistance to antiretrovirals in HIV-infected patients failing therapy: prevalence, risk factors and virological outcome.
Antiviral therapy - 1 Jan 2006
Tozzi Valerio, Zaccarelli Mauro, Bonfigli Sandro, Lorenzini Patrizia, Liuzzi Giuseppina, Trotta Maria Paola, Forbici Federica, Gori Caterina, Bertoli Ada, Bellagamba Rita, Narciso Pasquale, Perno Carlo Federico, Antinori Andrea
Abstract excerpt
BACKGROUND: Drug-class-wide resistance (DCWR) to antiretrovirals substantially reduces treatment options. METHODS: A database of 602 patients failing highly active antiretroviral therapy (HAART) undergoing genotypic resistance test (GRT) was analysed. DCWR was defined according to the International AIDS Society consensus. A multiple logistic regression model was built to define factors significantly associated...
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