Article
Evolution of drug resistance in HIV-infected patients remaining on a virologically failing combination antiretroviral therapy regimen.
AIDS (London, England) - 30 Mar 2007
Cozzi-Lepri Alessandro, Phillips Andrew N, Ruiz Lidia, Clotet Bonaventura, Loveday Clive, Kjaer Jesper, Mens Helene, Clumeck Nathan, Viksna Ludmila, Antunes Francisco, Machala Ladislav, Lundgren Jens D
Abstract excerpt
OBJECTIVE: To estimate the extent of drug resistance accumulation in patients kept on a virologically failing regimen and its determinants in the clinical setting. DESIGN: The study focused on 110 patients of EuroSIDA on an unchanged regimen who had two genotypic tests performed at two time points (t0 and t1) when viral load was > 400 copies/ml. METHODS: Accumulation of resistance between t0 and t1 was measured...
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