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Article

Polymorphic cytochrome P450 2D6: humanized mouse model and endogenous substrates.

Drug metabolism reviews - 1 May 2004

Yu Ai-Ming, Idle Jeffrey R, Gonzalez Frank J

Abstract excerpt

Cytochrome P450 2D6 (CYP2D6) is the first well-characterized polymorphic phase I drug-metabolizing enzyme, and more than 80 allelic variants have been identified for the CYP2D6 gene, located on human chromosome 22q13.1. Human debrisoquine and sparteine metabolism is subdivided into two principal phenotypes--extensive metabolizer and poor metabolizer--that arise from variant CYP2D6 genotypes. It has been estimated...

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Identifiers

PMID: 15237854
DOI: 10.1081/dmr-120034000

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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