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Article

Modeling human cytochrome P450 2D6 metabolism and drug-drug interaction by a novel panel of knockout and humanized mouse lines.

Molecular pharmacology - 1 Jan 2012

Scheer Nico, Kapelyukh Yury, McEwan Jillian, Beuger Vincent, Stanley Lesley A, Rode Anja, Wolf C Roland

Abstract excerpt

The highly polymorphic human cytochrome P450 2D6 enzyme is involved in the metabolism of up to 25% of all marketed drugs and accounts for significant individual differences in response to CYP2D6 substrates. Because of the differences in the multiplicity and substrate specificity of CYP2D family members among species, it is difficult to predict pathways of human CYP2D6-dependent drug metabolism on the basis of...

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Identifiers

PMID: 21989258
DOI: 10.1124/mol.111.075192

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