Article
Interleukin 6-174 G/C promoter gene polymorphism in centenarians: no evidence of association with human longevity or interaction with apolipoprotein E alleles.
Experimental gerontology - 1 Jul 2004
Capurso Cristiano, Solfrizzi Vincenzo, D'Introno Alessia, Colacicco Anna M, Capurso Sabrina A, Semeraro Cosimo, Capurso Antonio, Panza Francesco
Abstract excerpt
The C allele at position -174 in the promoter of the interleukin 6 (IL-6) gene has been associated with reduced gene expression and reduced plasma levels of IL-6. Given that IL-6 tracks with functional disability and age-related diseases, there may be attrition or reduction in the frequency of the homozygous subjects, who produce higher IL-6 serum levels, in older survivors in a population. In fact, a marked...
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