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Interleukin 6-174 G/C promoter gene polymorphism and sporadic Alzheimer's disease: geographic allele and genotype variations in Europe.

Experimental gerontology - 1 Oct 2004

Capurso Cristiano, Solfrizzi Vincenzo, D'Introno Alessia, Colacicco Anna M, Capurso Sabrina A, Capurso Antonio, Panza Francesco

Abstract excerpt

The interleukin 6 (IL-6) gene in humans is located in the short arm of chromosome 7 and has a-174 G/C polymorphism in its promoter region. The C allele at position-174 in the promoter of the interleukin 6 (IL-6) gene has been associated with reduced gene expression and reduced plasma levels of IL-6. Given the supposed role of several inflammatory mediators in neurodegeneration and Alzheimer's disease (AD), the...

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Aged
Alzheimer Disease
Apolipoproteins E
Gene Frequency
Genetic Predisposition to Disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Polymorphism, Genetic

Promoter Regions, Genetic

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Identifiers

PMID: 15501028
DOI: 10.1016/j.exger.2004.07.006

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APOE

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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Interleukin 6-174 G/C promoter gene polymorphism and sporadic Alzheimer's disease: geographic allele and genotype variations in Europe.PMID 15501028Read ↗

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