Effect of interleukin-6 polymorphisms on human longevity: a systematic review and meta-analysis.

doi:10.1016/j.arr.2008.09.001

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Article

Effect of interleukin-6 polymorphisms on human longevity: a systematic review and meta-analysis.

Ageing research reviews - 1 Jan 2009

Di Bona Danilo, Vasto Sonya, Capurso Cristiano, Christiansen Lene, Deiana Luca, Franceschi Claudio, Hurme Mikko, Mocchegiani Eugenio, Rea Maeve, Lio Domenico, Candore Giuseppina, Caruso Calogero

Abstract excerpt

Several studies have assessed changes in frequency of -174 interleukin (IL)-6 single nucleotide polymorphism (SNP) with age. If IL-6 tracks with disability and age-related diseases, then there should be reduction, in the oldest old, of the frequency of homozygous GG subjects, who produce higher IL-6 levels. However, discordant results have been obtained. To explore the relationship between this polymorphism and...

Topics

Aged, 80 and over
Environment
Gene Frequency
Genotype
Humans
Interleukin-6
Longevity
Odds Ratio
Polymorphism, Single Nucleotide

Source

Open in PubMed

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Identifiers

PMID: 18930842
DOI: 10.1016/j.arr.2008.09.001

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