Article
Associations of the -174 G/C interleukin-6 gene promoter polymorphism with serum interleukin 6 and mortality in the elderly.
Biogerontology - 1 Dec 2005
Ravaglia Giovanni, Forti Paola, Maioli Fabiola, Chiappelli Martina, Dolzani Paolo, Martelli Mabel, Bianchin Marisa, Mariani Erminia, Bolondi Luigi, Licastro Federico
Abstract excerpt
Serum interleukin-6 (sIL6) is an acknowledged predictor of all-cause mortality in older age. A common G/C polymorphism has been identified at position -174 of the IL6 gene promoter (IL6-174G>C), but its associations with sIL6 and mortality are still unclear. Data from a population-based elderly cohort (n=824) were used to study the associations of baseline sIL6 with the IL6-174 C-allele (C+) carrier status and...
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