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Article

Outflow tract cushions perform a critical valve-like function in the early embryonic heart requiring BMPRIA-mediated signaling in cardiac neural crest.

American journal of physiology. Heart and circulatory physiology - 1 Nov 2009

Nomura-Kitabayashi Aya, Phoon Colin K L, Kishigami Satoshi, Rosenthal Julie, Yamauchi Yasutaka, Abe Kuniya, Yamamura Ken-ichi, Samtani Rajeev, Lo Cecilia W, Mishina Yuji

Abstract excerpt

Neural crest-specific ablation of BMP type IA receptor (BMPRIA) causes embryonic lethality by embryonic day (E) 12.5, and this was previously postulated to arise from a myocardial defect related to signaling by a small population of cardiac neural crest cells (cNCC) in the epicardium. However, as BMP signaling via cNCC is also required for proper development of the outflow tract cushions, precursors to the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 19717734
DOI: 10.1152/ajpheart.00304.2009
PMCID: PMC2781366

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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