Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

An essential role for Notch in neural crest during cardiovascular development and smooth muscle differentiation.

The Journal of clinical investigation - 1 Feb 2007

High Frances A, Zhang Maozhen, Proweller Aaron, Tu Lili, Parmacek Michael S, Pear Warren S, Epstein Jonathan A

Abstract excerpt

The cardiac outflow tract develops as a result of a complex interplay among several cell types, including cardiac neural crest cells, endothelial cells, and cardiomyocytes. In both humans and mice, mutations in components of the Notch signaling pathway result in congenital heart disease characterized by cardiac outflow tract defects. However, the specific cell types in which Notch functions during cardiovascular...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cardiovascular Abnormalities
Share to Cardiovascular System

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cell Differentiation

Share to In Vitro Techniques

Share to Mice, Mutant Strains

Share to Muscle, Smooth

Share to Neural Crest

Share to Receptors, Notch

Source

Open in PubMed Open full text

Identifiers

PMID: 17273555
DOI: 10.1172/JCI30070
PMCID: PMC1783803

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

An essential role for Notch in neural crest during cardiovascular development and smooth muscle differentiation.PMID 17273555Read ↗

Notch2 is required for the proliferation of cardiac neural crest-derived smooth muscle cells.Semantic proximity Read ↗

Neural crest and cardiovascular development: a 20-year perspective.Semantic proximity Read ↗

ROLE OF CARDIAC NEURAL CREST CELLS IN CARDIOVASCULAR DEVELOPMENTSemantic proximity Read ↗

The Cardiac Neural Crest Cells in Heart Development and Congenital Heart DefectsSemantic proximity Read ↗

Notch signalling in smooth muscle cells during development and disease.Semantic proximity Read ↗

Notch Signaling in Cardiac DevelopmentSemantic proximity Read ↗

Temporal-spatial ablation of neural crest in the mouse results in cardiovascular defects.Semantic proximity Read ↗

N-cadherin is required for neural crest remodeling of the cardiac outflow tract.Semantic proximity Read ↗

Sonic hedgehog is required for cardiac outflow tract and neural crest cell developmentSemantic proximity Read ↗

Loss of microRNAs in neural crest leads to cardiovascular syndromes resembling human congenital heart defects.Semantic proximity Read ↗

Notch pathway regulation of neural crest cell development in vivoSemantic proximity Read ↗

Evolutionary and developmental origins of the cardiac neural crest: Building a divided outflow tractSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.