Article

Ankrd11, a chromatin regulator and a KBG syndrome risk gene, is a critical regulator of cardiac neural crest cell biology and heart development

2023-02-24

Abstract excerpt

<title>Abstract</title> <p>ANKRD11 (Ankyrin Repeat Domain 11) is a chromatin regulator and a risk gene for KBG syndrome, a rare developmental disorder characterized by multiple organ abnormalities, including cardiac defects. However, the role of ANKRD11 in heart development is unknown. The neural crest plays a leading role in embryonic heart development, and its dysfunction is implicated in many congenital heart...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 3b3879b1-dc34-52ed-9b54-8f15bc213475
DOI: 10.21203/rs.3.rs-2605378/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Ankrd11, a chromatin regulator and a KBG syndrome risk gene, is a critical regulator of cardiac neural crest cell biology and heart developmentDOI 10.21203/rs.3.rs-2605378/v1Read

The chromatin regulator Ankrd11 controls cardiac neural crest cell-mediated outflow tract remodeling and heart functionSemantic proximity Read

Olfactory bulb anomalies in KBG syndrome mouse model and patientsSemantic proximity Read

Further delineation of the KBG syndrome phenotype caused by ANKRD11 aberrations.Semantic proximity Read

The Cardiac Neural Crest Cells in Heart Development and Congenital Heart DefectsSemantic proximity Read

Cardiac outflow tract defects in mice lacking ALK2 in neural crest cells.Semantic proximity Read

Neural crest cell derived DKK1 modulates Wnt signalling in the second heart field to orchestrate cardiac outflow tract developmentSemantic proximity Read

Genetic and Epigenetic Control of Heart Development.Semantic proximity Read

Mechanisms underlying the role of ankyrin-B in cardiac and neurological health and diseaseSemantic proximity Read

Cardiac Neural Crest Expression of Hand2 Regulates Outflow and Second Heart Field DevelopmentSemantic proximity Read

Neural crest and cardiovascular development: a 20-year perspective.Semantic proximity Read

Pinch1 is required for normal development of cranial and cardiac neural crest-derived structures.Semantic proximity Read

Human trunk embryoids with patterned anterior-posterior and dorsal-ventral body axes: utility for understanding human development and diseaseSemantic proximity Read