Article
Internal lysine palmitoylation in adenylate cyclase toxin from Bordetella pertussis.
Science (New York, N.Y.) - 21 Oct 1994
Hackett M, Guo L, Shabanowitz J, Hunt D F, Hewlett E L
Abstract excerpt
A number of bacterial protein toxins, including adenylate cyclase (AC) toxin from Bordetella pertussis, require the product of an accessory gene in order to express their biological activities. In this study, mass spectrometry was used to demonstrate that activated, wild-type AC toxin was modified by amide-linked palmitoylation on the epsilon-amino group of lysine 983. This modification was absent from a mutant...
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