Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Human DNA methyltransferase 1 is required for maintenance of the histone H3 modification pattern.

The Journal of biological chemistry - 27 Aug 2004

Espada Jesus, Ballestar Esteban, Fraga Mario F, Villar-Garea Ana, Juarranz Angeles, Stockert Juan C, Robertson Keith D, Fuks François, Esteller Manel

Abstract excerpt

DNA methyltransferase 1 (DNMT1) plays an essential role in murine development and is thought to be the enzyme primarily responsible for maintenance of the global methylation status of genomic DNA. However, loss of DNMT1 in human cancer cells affects only the methylation status of a limited number of pericentromeric sequences. Here we show that human cancer cells lacking DNMT1 display at least two important...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chromobox Protein Homolog 5
Share to Chromosomal Proteins, Non-Histone

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to DNA (Cytosine-5-)-Methyltransferase 1

Share to DNA (Cytosine-5-)-Methyltransferases

Share to Electrophoresis, Capillary

Share to Heterochromatin

Share to Histone Deacetylases

Share to Micrococcal Nuclease

Source

Identifiers

PMID: 15220328
DOI: 10.1074/jbc.M404842200

Genes

DNMT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Human DNA methyltransferase 1 is required for maintenance of the histone H3 modification pattern.PMID 15220328Read ↗

Mediating and maintaining methylation while minimizing mutation: Recent advances on mammalian DNA methyltransferases.Semantic proximity Read ↗

DNMT3B PWWP mutations cause hypermethylation of heterochromatin.Semantic proximity Read ↗

Dnmt3a protects active chromosome domains against cancer-associated hypomethylation.Semantic proximity Read ↗

Histone H3 mutations and their impact on genome stability maintenance.Semantic proximity Read ↗

Mammalian (cytosine-5) methyltransferases cause genomic DNA methylation and lethality in Drosophila.Semantic proximity Read ↗

DNMT3B PWWP mutations cause hypermethylation of heterochromatinSemantic proximity Read ↗

DNA hypermethylation in Drosophila melanogaster causes irregular chromosome condensation and dysregulation of epigenetic histone modifications.Semantic proximity Read ↗

Crystal Structure of Human DNA Methyltransferase 1.Semantic proximity Read ↗

Dnmt3b Prefers Germ Line Genes and Centromeric Regions: Lessons from the ICF Syndrome and Cancer and Implications for DiseasesSemantic proximity Read ↗

The N-terminal region of DNMT3A combines multiple chromatin reading motifs to guide recruitmentSemantic proximity Read ↗

Analysis of Genomic DNA Methylation and Gene Transcription Modulation Induced by DNMT3A Deficiency in HEK293 CellsSemantic proximity Read ↗

Mouse embryonic stem cells exhibit cancer-like DNA methylation landscapes upon DNMT1 overexpressionSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.