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Dnmt3b Prefers Germ Line Genes and Centromeric Regions: Lessons from the ICF Syndrome and Cancer and Implications for Diseases

5 Sept 2014

Abstract excerpt

The correct establishment and maintenance of DNA methylation patterns are critical for mammalian development and the control of normal cell growth and differentiation. DNA methylation has profound effects on the mammalian genome, including transcriptional repression, modulation of chromatin structure, X chromosome inactivation, genomic imprinting, and the suppression of the detrimental effects of repetitive and...

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Share to Epigenetics and DNA Methylation
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Share to Prenatal Screening and Diagnostics

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 25198254
DOI: 10.3390/biology3030578

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Related research

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Dnmt3b Prefers Germ Line Genes and Centromeric Regions: Lessons from the ICF Syndrome and Cancer and Implications for DiseasesPMID 25198254Read ↗

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Comparative methylome analysis of ICF patients identifies heterochromatin loci that require ZBTB24, CDCA7 and HELLS for their methylated state.Semantic proximity Read ↗

DNMT3b protects centromere integrity by restricting R-loop-mediated DNA damage.Semantic proximity Read ↗

Genome-Wide DNA Methylation Analysis Identifies Novel Hypomethylated Non-Pericentromeric Genes with Potential Clinical Implications in ICF Syndrome.Semantic proximity Read ↗

DNMT3B mutations and DNA methylation defect define two types of ICF syndrome.Semantic proximity Read ↗

Mutations in ZBTB24 are associated with immunodeficiency, centromeric instability, and facial anomalies syndrome type 2.Semantic proximity Read ↗

Chromatin remodeling in replication‐uncoupled maintenance DNA methylation and chromosome stability: Insights from ICF syndrome studiesSemantic proximity Read ↗

ICF syndrome mutations cause a broad spectrum of biochemical defects in DNMT3B-mediated de novo DNA methylation.Semantic proximity Read ↗

Roles for Dnmt3b in mammalian development: a mouse model for the ICF syndrome.Semantic proximity Read ↗

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