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Article

Identification of a nuclear localization signal in OCT4 and generation of a dominant negative mutant by its ablation.

The Journal of biological chemistry - 27 Aug 2004

Pan Guangjin, Qin Baomin, Liu Nan, Schöler Hans R, Pei Duanqing

Abstract excerpt

OCT4 plays a critical role in maintaining stem cell pluripotency in a dose-dependent manner by activating and repressing multiple downstream genes. The precise mechanism by which OCT4 achieves these diverse biological functions remains unknown. In this report, we identify and characterize (195)RK...

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Identifiers

PMID: 15218026
DOI: 10.1074/jbc.M405117200

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-15218026-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

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Identification of a nuclear localization signal in OCT4 and generation of a dominant negative mutant by its ablation.PMID 15218026Read ↗

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Identification of the TBX5 transactivating domain and the nuclear localization signal.Semantic proximity Read ↗

Transcriptional activation by Oct4 is sufficient for the maintenance and induction of pluripotency.Semantic proximity Read ↗

Functional interplay between the RK motif and linker segment dictates Oct4-DNA recognition.Semantic proximity Read ↗

G protein-coupled receptor kinase 5 contains a DNA-binding nuclear localization sequence.Semantic proximity Read ↗

KDEL tagging: a method for generating dominant-negative inhibitors of the secretion of TGF-beta superfamily proteins.Semantic proximity Read ↗

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TBX5 nuclear localization is mediated by dual cooperative intramolecular signals.Semantic proximity Read ↗

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