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Article

Establishment of a tagged variant of Lgr4 receptor suitable for functional and expression studies in the mouse.

Transgenic research - 1 Oct 2017

Kriz Vitezslav, Krausova Michaela, Buresova Petra, Dobes Jan, Hrckulak Dusan, Babosova Olga, Svec Jiri, Korinek Vladimir

Abstract excerpt

Leucine-rich repeat-containing G-protein-coupled receptor 4 (LGR4) is produced in a broad spectrum of mouse embryonic and adult tissues and its deficiency results in embryonal or perinatal lethality. The LGR4 function was mainly related to its potentiation of canonical Wnt signaling; however, several recent studies associate LGR4 with additional signaling pathways. To obtain a suitable tool for studying the...

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Identifiers

PMID: 28634819
DOI: 10.1007/s11248-017-0027-0
PMCID: PMC5602029

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