Article
Identification of the nuclear localization signal of SALL4B, a stem cell transcription factor.
Cell cycle (Georgetown, Tex.) - 1 Jan 2014
Wu Meng, Yang Feikun, Ren Zhihua, Jiang Yongping, Ma Yupo, Chen Yan, Dai Wei
Abstract excerpt
SALL4B plays a critical role in maintaining the pluripotency of embryonic stem cells and hematopoietic stem cells. SALL4B primarily functions as a transcription factor, and, thus, its nuclear localization is paramount to its biological activities. To understand the structural basis by which SALL4B was transported and retained in the nucleus, we made a series of SALL4B constructs with deletions or point mutations....
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