Article
Transcriptional activation by Oct4 is sufficient for the maintenance and induction of pluripotency.
Cell reports - 23 Feb 2012
Hammachi Fella, Morrison Gillian M, Sharov Alexei A, Livigni Alessandra, Narayan Santosh, Papapetrou Eirini P, O'Malley James, Kaji Keisuke, Ko Minoru S H, Ptashne Mark, Brickman Joshua M
Abstract excerpt
Oct4 is an essential regulator of pluripotency in vivo and in vitro in embryonic stem cells, as well as a key mediator of the reprogramming of somatic cells into induced pluripotent stem cells. It is not known whether activation and/or repression of specific genes by Oct4 is relevant to these functions. Here, we show that fusion proteins containing the coding sequence of Oct4 or Xlpou91 (the Xenopus homolog of...
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