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Article

Functional interplay between the RK motif and linker segment dictates Oct4-DNA recognition.

Nucleic acids research - 19 May 2015

Kong Xiangqian, Liu Jian, Li Lianchun, Yue Liyan, Zhang Lihong, Jiang Hualiang, Xie Xin, Luo Cheng

Abstract excerpt

The POU family transcription factor Oct4 plays pivotal roles in regulating pluripotency and somatic cell reprogramming. Previous studies have indicated an important role for major groove contacts in Oct4-DNA recognition; however, the contributions of the RK motif in the POUh domain and the linker segment joining the two DNA-binding domains remain poorly understood. Here, by combining molecular modelling and...

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PMID: 25870414
DOI: 10.1093/nar/gkv323
PMCID: PMC4482079

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