Translation initiation with 70S ribosomes: an alternative pathway for leaderless mRNAs.

doi:10.1093/nar/gkh663

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Article

Translation initiation with 70S ribosomes: an alternative pathway for leaderless mRNAs.

Nucleic acids research - 1 Jan 2004

Moll Isabella, Hirokawa Go, Kiel Michael C, Kaji Akira, Bläsi Udo

Abstract excerpt

It is generally accepted that translation in bacteria is initiated by 30S ribosomal subunits. In contrast, several lines of rather indirect in vitro evidence suggest that 70S monosomes are capable of initiating translation of leaderless mRNAs, starting with the A of the initiation codon. In this study, we demonstrate the proficiency of dedicated 70S ribosomes in in vitro translation of leaderless mRNAs. In...

Topics

5' Untranslated Regions
Codon, Initiator
Escherichia coli
Gene Expression Regulation, Bacterial
Genes, Bacterial
Models, Genetic
Mutation
Peptide Chain Initiation, Translational
RNA, Messenger
Ribosomes

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Identifiers

PMID: 15215335
DOI: 10.1093/nar/gkh663
PMCID: PMC443539

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