Article
The ATPase Fap7 Tests the Ability to Carry Out Translocation-like Conformational Changes and Releases Dim1 during 40S Ribosome Maturation.
Molecular cell - 21 Sept 2017
Ghalei Homa, Trepreau Juliette, Collins Jason C, Bhaskaran Hari, Strunk Bethany S, Karbstein Katrin
Abstract excerpt
Late in their maturation, nascent small (40S) ribosomal subunits bind 60S subunits to produce 80S-like ribosomes. Because of the analogy of this translation-like cycle to actual translation, and because 80S-like ribosomes do not produce any protein, it has been suggested that this represents a quality control mechanism for subunit functionality. Here we use genetic and biochemical experiments to show that the...
Topics
- Adenylate Kinase
- Frameshifting, Ribosomal
- Genotype
- Methyltransferases
- Models, Molecular
- Nuclear Proteins
- Nucleoside-Triphosphatase
- Phenotype
- Protein Binding
- Protein Conformation