Structure of a specialized 70S initiation complex.

doi:10.1093/nar/gkag094

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Article

Structure of a specialized 70S initiation complex.

Nucleic acids research - 19 Mar 2026

Arpin Dominic, Roy Bappaditya, Naeem Fawwaz M, Fredrick Kurt, Ortega Joaquin

Abstract excerpt

Bacteria of class Bacteroidia lack Shine-Dalgarno (SD) sequences and instead rely on other messenger RNA (mRNA) features, including upstream adenines, for start codon selection. Bacteroidia ribosomes contain the anti-SD (ASD) sequence of 16S ribosomal RNA (rRNA) but are "blind" to SD sequences. This occurs due to the sequestration of the ASD through interactions with bS21, bS18, and bS6 on the 30S platform...

Topics

RNA, Ribosomal, 16S
Ribosomes
Cryoelectron Microscopy
Flavobacterium
RNA, Messenger
Peptide Chain Initiation, Translational
Models, Molecular
Nucleic Acid Conformation
Bacterial Proteins
Ribosomal Proteins
Mutation

Source

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Identifiers

PMID: 41854077
DOI: 10.1093/nar/gkag094
PMCID: PMC13000457

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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