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Article

Smad5 determines murine amnion fate through the control of bone morphogenetic protein expression and signalling levels.

Development (Cambridge, England) - 1 Sept 2006

Bosman Erika A, Lawson Kirstie A, Debruyn Joke, Beek Lisette, Francis Annick, Schoonjans Luc, Huylebroeck Danny, Zwijsen An

Abstract excerpt

Smad5 is an intracellular mediator of bone morphogenetic protein (Bmp) signalling. It is essential for primordial germ cell (PGC) development, for the development of the allantois and for amnion closure, as demonstrated by loss of Bmp signalling. By contrast, the appearance of ectopic PGC-like cells and regionalized ectopic vasculogenesis and haematopoiesis in thickened Smad5(m1/m1) amnion are amnion defects that...

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PMID: 16887830
DOI: 10.1242/dev.02497

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PGC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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