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Article

Essential role of Smad4 in maintaining cardiomyocyte proliferation during murine embryonic heart development.

Developmental biology - 1 Nov 2007

Qi Xin, Yang Guan, Yang Leilei, Lan Yu, Weng Tujun, Wang Jian, Wu Zhuang, Xu Jun, Gao Xiang, Yang Xiao

Abstract excerpt

Transforming growth factor-beta/bone morphogenetic protein (TGF-beta/BMP) signaling pathway is essential for embryonic and postnatal heart development and remodeling. The intracellular factor Smad4 plays a pivotal role in mediating TGF-beta/BMP signal transduction in the nucleus. To examine the function of Smad4 in embryonic cardiac development during mid-gestation, we specifically deleted the Smad4 gene in...

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Share to Cell Proliferation
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 17869237
DOI: 10.1016/j.ydbio.2007.08.022

Genes

GATA4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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