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Article

Candida glabrata erg1 mutant with increased sensitivity to azoles and to low oxygen tension.

Antimicrobial agents and chemotherapy - 1 Jul 2004

Tsai Huei-Fung, Bard Martin, Izumikawa Koichi, Krol Anna A, Sturm Aaron M, Culbertson Nicholas T, Pierson Charles A, Bennett John E

Abstract excerpt

A Candida glabrata erg1 (Cgerg1) mutant, CgTn201S, was identified by transposon mutagenesis and by increased fluconazole susceptibility. CgERG1 encodes a 489-amino-acid protein which, on the basis of its homology with Saccharomyces cerevisiae ERG1, is a squalene epoxidase essential for ergosterol synthesis. Interruption following codon 475 of CgErg1p decreased the ergosterol content by 50%; caused accumulation of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 15215098
DOI: 10.1128/AAC.48.7.2483-2489.2004
PMCID: PMC434157

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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