Article
Loss of C-5 Sterol Desaturase Activity Results in Increased Resistance to Azole and Echinocandin Antifungals in a Clinical Isolate of Candida parapsilosis.
Antimicrobial agents and chemotherapy - 1 Sept 2017
Rybak Jeffrey M, Dickens C Michael, Parker Josie E, Caudle Kelly E, Manigaba Kayihura, Whaley Sarah G, Nishimoto Andrew T, Luna-Tapia Arturo, Roy Sujoy, Zhang Qing, Barker Katherine S, Palmer Glen E, Sutter Thomas R, Homayouni Ramin, Wiederhold Nathan P, Kelly Steven L, Rogers P David
Abstract excerpt
Among emerging non-albicans Candida species, Candida parapsilosis is of particular concern as a cause of nosocomial bloodstream infections in neonatal and intensive care unit patients. While fluconazole and echinocandins are considered effective treatments for such infections, recent reports of fluconazole and echinocandin resistance in C. parapsilosis indicate a growing problem. The present study describes a...
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