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Article

Candida albicans mutations in the ergosterol biosynthetic pathway and resistance to several antifungal agents.

Antimicrobial agents and chemotherapy - 1 Aug 2003

Sanglard Dominique, Ischer Françoise, Parkinson Tania, Falconer Derek, Bille Jacques

Abstract excerpt

The role of sterol mutations in the resistance of Candida albicans to antifungal agents has not been thoroughly investigated. Previous work reported that clinical C. albicans strains resistant to both azole antifungals and amphotericin B were defective in ERG3, a gene encoding sterol Delta(5,6)-desaturase. It is also believed that a deletion of the lanosterol 14alpha-demethylase gene, ERG11, is possible only...

Topics

Aerobiosis
Antifungal Agents
Blotting, Northern
Blotting, Southern
Candida albicans
DNA Probes
Drug Resistance, Fungal
Ergosterol
Microbial Sensitivity Tests
Mutation
Oxidoreductases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Phenotype

Reverse Transcriptase Polymerase Chain Reaction

Source

Open in PubMed Open full text

Identifiers

PMID: 12878497
DOI: 10.1128/AAC.47.8.2404-2412.2003
PMCID: PMC166068

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