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Article

Sequencing, disruption, and characterization of the Candida albicans sterol methyltransferase (ERG6) gene: drug susceptibility studies in erg6 mutants.

Antimicrobial agents and chemotherapy - 1 May 1998

Jensen-Pergakes K L, Kennedy M A, Lees N D, Barbuch R, Koegel C, Bard M

Abstract excerpt

The rise in the frequency of fungal infections and the increased resistance noted to the widely employed azole antifungals make the development of new antifungals imperative for human health. The sterol biosynthetic pathway has been exploited for the development of several antifungal agents (allylamines, morpholines, azoles), but additional potential sites for antifungal agent development are yet to be fully...

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Identifiers

PMID: 9593144
DOI: 10.1128/AAC.42.5.1160
PMCID: PMC105764

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Sequencing, disruption, and characterization of the Candida albicans sterol methyltransferase (ERG6) gene: drug susceptibility studies in erg6 mutants.PMID 9593144Read ↗

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