Article
Sequencing, disruption, and characterization of the Candida albicans sterol methyltransferase (ERG6) gene: drug susceptibility studies in erg6 mutants.
Antimicrobial agents and chemotherapy - 1 May 1998
Jensen-Pergakes K L, Kennedy M A, Lees N D, Barbuch R, Koegel C, Bard M
Abstract excerpt
The rise in the frequency of fungal infections and the increased resistance noted to the widely employed azole antifungals make the development of new antifungals imperative for human health. The sterol biosynthetic pathway has been exploited for the development of several antifungal agents (ally...
Topics
- Amino Acid Sequence
- Antifungal Agents
- Base Sequence
- Candida albicans
- Fungal Proteins
- Genes, Fungal
- Heterozygote
- Methyltransferases
- Microbial Sensitivity Tests
- Molecular Sequence Data
- Mutation
- Sequence Alignment
- Sequence Homology, Amino Acid