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Article

Identification and characterization of four azole-resistant erg3 mutants of Candida albicans.

Antimicrobial agents and chemotherapy - 1 Nov 2010

Martel Claire M, Parker Josie E, Bader Oliver, Weig Michael, Gross Uwe, Warrilow Andrew G S, Rolley Nicola, Kelly Diane E, Kelly Steven L

Abstract excerpt

Sterol analysis identified four Candida albicans erg3 mutants in which ergosta 7,22-dienol, indicative of perturbations in sterol Δ(5,6)-desaturase (Erg3p) activity, comprised >5% of the total sterol fraction. The erg3 mutants (CA12, CA488, CA490, and CA1008) were all resistant to fluconazole, voriconazole, itraconazole, ketoconazole, and clotrimazole under standard CLSI assay conditions (MIC values, ≥256, 16,...

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Identifiers

PMID: 20733039
DOI: 10.1128/AAC.00348-10
PMCID: PMC2976150

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Source receipt: pubmed, retrieved 7 Sept 2026.

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