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Article

Is COMT a susceptibility gene for schizophrenia?

Schizophrenia bulletin - 1 May 2007

Williams Hywel J, Owen Michael J, O'Donovan Michael C

Abstract excerpt

Catechol-O-methyl transferase (COMT) is a catabolic enzyme involved in the degradation of a number of bioactive molecules; of principal interest to psychiatry, these include dopamine. The enzyme is encoded by the COMT gene. COMT is located (along with 47 other genes) in a fragment of chromosome 22q11 which when deleted results in a complex syndrome, the psychiatric manifestations of which include schizophrenia...

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Source

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Identifiers

PMID: 17412710
DOI: 10.1093/schbul/sbm019
PMCID: PMC2526139

Genes

COMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

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Is COMT a susceptibility gene for schizophrenia?PMID 17412710Read ↗

The catechol-O-methyl transferase (COMT) gene as a candidate for psychiatric phenotypes: evidence and lessons.Semantic proximity Read ↗

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Association studies of catechol-O-methyltransferase (COMT) gene with schizophrenia and response to antipsychotic treatment.Semantic proximity Read ↗

COMT: a common susceptibility gene in bipolar disorder and schizophrenia.Semantic proximity Read ↗

Association between Val108/158 Met polymorphism of the COMT gene and schizophrenia.Semantic proximity Read ↗

Separate and interacting effects within the catechol-O-methyltransferase (COMT) are associated with schizophrenia.Semantic proximity Read ↗

Association of Ala72Ser polymorphism with COMT enzyme activity and the risk of schizophrenia in Koreans.Semantic proximity Read ↗

Functional catechol-O-methyltransferase gene polymorphism and susceptibility to schizophrenia.Semantic proximity Read ↗

No associations exist between five functional polymorphisms in the catechol-O-methyltransferase gene and schizophrenia in a Japanese population.Semantic proximity Read ↗

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