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Article

Interaction of CTSD and A2M polymorphisms in the risk for Alzheimer's disease.

Journal of the neurological sciences - 25 Sept 2006

Mariani Elena, Seripa Davide, Ingegni Tiziana, Nocentini Giuseppe, Mangialasche Francesca, Ercolani Sara, Cherubini Antonio, Metastasio Antonio, Pilotto Alberto, Senin Umberto, Mecocci Patrizia

Abstract excerpt

The proteins cathepsin D, encoded by CTSD gene, and alpha2-macroglobulin, encoded by A2M gene, are involved in the biochemical pathway leading to deposition of beta-amyloid. In these proteins two amino acid polymorphisms (CTSD-Ala/Val C-->T and A2M-Ile/Val A-->G) have been associated with an increased risk for Alzheimer's disease (AD), but conflicting results have been reported. We studied the association and the...

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Source

Identifiers

PMID: 16784755
DOI: 10.1016/j.jns.2006.05.043

Genes

CTSD
APOE

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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