Article
Genetic associations between cathepsin D exon 2 C-->T polymorphism and Alzheimer's disease, and pathological correlations with genotype.
Journal of neurology, neurosurgery, and psychiatry - 1 Apr 2006
Davidson Y, Gibbons L, Pritchard A, Hardicre J, Wren J, Tian J, Shi J, Stopford C, Julien C, Thompson J, Payton A, Thaker U, Hayes A J, Iwatsubo T, Pickering-Brown S M, Pendleton N, Horan M A, Burns A, Purandare N, Lendon C L, Neary D, Snowden J S, Mann D M A
Abstract excerpt
Genetic variations represent major risk factors for Alzheimer's disease (AD). While familial early onset AD is associated with mutations in the amyloid precursor protein and presenilin genes, only the e4 allele of the apolipoprotein E (APOE) gene has so far been established as a genetic risk factor for late onset familial and sporadic AD. It has been suggested that the C-->T (224Ala-->Val) transition within exon...
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