Article
Expression of alpha-tryptase and beta-tryptase by human basophils.
The Journal of allergy and clinical immunology - 1 Jun 2004
Jogie-Brahim Sherryline, Min Hae-Ki, Fukuoka Yoshihiro, Xia Han-Zhang, Schwartz Lawrence B
Abstract excerpt
BACKGROUND: Alpha and beta-tryptase levels in serum are clinical tools for the evaluation of systemic anaphylaxis and systemic mastocytosis. Basophils and mast cells are known to produce these proteins. OBJECTIVE: The current study examines the effect of the alpha,beta-tryptase genotype on basophil tryptase levels and the type of tryptase stored in these cells. METHODS: Tryptase extracted from purified peripheral...
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