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Article

Hereditary Alpha-Tryptasemia and Mastocytosis: What We Know and What We Need To Learn.

Current allergy and asthma reports - 9 Mar 2026

Rama Tiago A, Gulen Theo

Abstract excerpt

PURPOSE OF REVIEW: This review aims to elucidate the evolving relationship between hereditary alpha-tryptasemia (HαT) and mastocytosis, emphasizing recent advances in understanding shared pathophysiological mechanisms, diagnostic challenges, and clinical implications. RECENT FINDINGS: HαT is a common genetic trait caused by increased copy numbers of the TPSAB1 gene encoding alpha-tryptase. It accounts for most...

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Anaphylaxis
DNA Copy Number Variations
Genetic Predisposition to Disease
Genotype
Mast Cells

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41801525
DOI: 10.1007/s11882-026-01262-9
PMCID: PMC12971857

Genes

TPSAB1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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