Article
Alpha-tryptase gene variation is associated with levels of circulating IgE and lung function in asthma.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology - 1 Jun 2014
Abdelmotelb A M, Rose-Zerilli M J, Barton S J, Holgate S T, Walls A F, Holloway J W
Abstract excerpt
BACKGROUND: Tryptase, a major secretory product of human mast cells has been implicated as a key mediator of allergic inflammation. Genetic variation in the tryptases is extensive, and α-tryptase, an allelic variant of the more extensively studied β-tryptase, is absent in substantial numbers of the general population. The degree to which α-tryptase expression may be associated with asthma has not been studied. We...
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