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Article

Human subjects are protected from mast cell tryptase deficiency despite frequent inheritance of loss-of-function mutations.

The Journal of allergy and clinical immunology - 1 Nov 2009

Trivedi Neil N, Tamraz Bani, Chu Catherine, Kwok Pui-Yan, Caughey George H

Abstract excerpt

BACKGROUND: Mast cell tryptases have proposed roles in allergic inflammation and host defense against infection. Tryptase gene loci TPSAB1 and TPSB2 are known to be polymorphic, but the nature and extent of diversity at these loci have not been fully explored. OBJECTIVE: We sought to compare func...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 19748655
DOI: 10.1016/j.jaci.2009.07.026
PMCID: PMC2783561

Genes

TPSAB1
TPSB2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19748655-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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