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Article

Genetic deficiency of human mast cell alpha-tryptase.

Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology - 1 Jul 2002

Soto D, Malmsten C, Blount J L, Muilenburg D J, Caughey G H

Abstract excerpt

BACKGROUND: Human alpha- and beta-tryptases are proteases secreted by mast cells. Beta (but not alpha) tryptases are implicated in asthma. Genes encoding both types of tryptases cluster on chromosome 16p13.3. OBJECTIVE: This study examines the hypothesis, generated from mapping data, that alpha-alleles compete with some beta-alleles at one locus and that an adjacent locus contains beta-alleles exclusively. This...

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Source

Identifiers

PMID: 12100045
DOI: 10.1046/j.1365-2222.2002.01416.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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