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Article

Incorporating Tryptase Genotyping Into the Workup and Diagnosis of Mast Cell Diseases and Reactions.

The journal of allergy and clinical immunology. In practice - 1 Aug 2022

Lyons Jonathan J, Greiner Georg, Hoermann Gregor, Metcalfe Dean D

Abstract excerpt

The measurement of mast cell tryptase levels in serum has found utility in the diagnosis and management of both clonal mast cell disorders and severe mast cell-dependent systemic reactions in the form of anaphylaxis. A more recent discovery is that a majority of individuals with elevated basal serum tryptase levels have increased germline TPSAB1 gene copy number encoding α-tryptase. This genetic trait is referred...

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Identifiers

PMID: 35597543
DOI: 10.1016/j.jaip.2022.05.003

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

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Research trail→

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Incorporating Tryptase Genotyping Into the Workup and Diagnosis of Mast Cell Diseases and Reactions.PMID 35597543Read ↗

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