Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Hereditary Alpha-Tryptasemia: a Commonly Inherited Modifier of Anaphylaxis.

Current allergy and asthma reports - 10 May 2021

Wu Richard, Lyons Jonathan J

Abstract excerpt

PURPOSE OF REVIEW: Hereditary alpha-tryptasemia (HαT) is an autosomal dominant genetic trait and a common cause of elevated basal serum tryptase in Western populations. It is a risk factor for severe anaphylaxis among individuals with venom allergy and an established modifier of anaphylaxis and mast cell mediator-associated symptoms among patients with systemic mastocytosis. Understanding the physiology of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Anaphylaxis
Share to Asthma and respiratory diseases
Share to Genotype

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mast Cells

Share to Mast cells and histamine

Share to Mastocytosis

Share to Phenotype

Share to Tryptases

Source

Identifiers

PMID: 33970354
DOI: 10.1007/s11882-021-01010-1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Hereditary Alpha-Tryptasemia: a Commonly Inherited Modifier of Anaphylaxis.PMID 33970354Read ↗

Hereditary alpha-tryptasemiaSemantic proximity Read ↗

Hereditary Alpha-Tryptasemia (HαT) as a Risk Modifier for Severe Anaphylaxis.Semantic proximity Read ↗

Hereditary alpha-tryptasemia in 101 patients with mast cell activation–related symptomatology including anaphylaxisSemantic proximity Read ↗

Hereditary Alpha-Tryptasemia and Mastocytosis: What We Know and What We Need To Learn.Semantic proximity Read ↗

Appraisal of the evidence linking hereditary α-tryptasemia with mast cell disorders, hypermobility and dysautonomia.Semantic proximity Read ↗

Elevated Tryptase Level in a Child with Idiopathic Anaphylaxis: A Case of Hereditary Alpha-TryptasemiaSemantic proximity Read ↗

Incorporating Tryptase Genotyping Into the Workup and Diagnosis of Mast Cell Diseases and Reactions.Semantic proximity Read ↗

Heritable risk for severe anaphylaxis associated with increased α-tryptase-encoding germline copy number at TPSAB1.Semantic proximity Read ↗

Clinical impact of the TPSAB1 genotype in mast cell diseases: A REMA study in a cohort of 959 individuals.Semantic proximity Read ↗

The Clinical Features of Hereditary Alpha-Tryptasemia—Implications for Interdisciplinary Practice.Semantic proximity Read ↗

Mast cell activation syndrome: is anaphylaxis part of the phenotype? A systematic review.Semantic proximity Read ↗

Mast cell tryptases in allergic inflammation and immediate hypersensitivity.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.